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12/31/2006
Pediatr Allergy Immunol 17: 578-582, 2006
T lymphocytes accumulating in the skin of patients with atopic dermatitis (AD) have a prolonged survival and are key mediators of this inflammatory disease. The anti-apoptotic bfl-1 gene is unique in that it is the only member of the Bcl-2 family that is transcriptionally regulated by inflammatory cytokines and might therefore be important in promoting the survival of effector T cells in patients with AD. Etc.
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12/31/2006
Am J Transplant. 6: 1682-1688, 2006
The chronic shortage of deceased kidney donors has led to increased utilization of donation after cardiac death (DCD) kidneys, the majority of which are procured in a controlled setting. The objective of this study is to evaluate transplantation outcomes from uncontrolled DCD (uDCD) donors and evaluate their utility as a source of donor kidneys.
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12/31/2006
Pharmacogenomics J. 6: 301-310, 2006
The promise of drug individualization through pharmacogenomics will be evident initially in those patients who have the poorest therapeutic response or most severe adverse drug effects. In solid-organ transplantation, lung transplantation has the poorest outcome among the commonly transplanted major organs with less than 80% one-year and less than 50% fiveyear survival. Etc.
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12/31/2006
Ann Thoac Surg. 81:132-137, 2006
A systemic inflammatory response is not uncommonly observed after coronary revascularization. Tumor necrosis factor alpha is one of a number of modulators of this response. A functional polymorphism within the TNFa gene at position G-308A has been associated with increased TNFa levels. The relationship between predicted TNFa genotype and circulating TNFa levels in patients undergoing coronary revascularization surgery has yet to be defined. We examined the relationship between TNFa G-308A polymorphism, TNFa postoperative levels, and clinical outcome after coronary revascularization surgery.
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12/31/2006
Transplantation. 81:392-397, 2006
Recurrent hepatitis C virus (HCV) infection is particularly aggressive in the post liver transplantation setting, with rapid progression of liver fibrosis. Platelet-derived growth factor (PDGF) is reportedly involved in the pathogenesis of liver fibrosis. The aim of this study was to evaluate the possible contribution of molecular variants of the PDGF-B gene to recurrent HCV infection after liver transplantation.
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12/31/2006
Transplantation. 82:1677-1682, 2006
Variations in the expression and activity levels of the multidrug-resistance MDR1/ABCB1 encoded glycoprotein (P-gp) have an impact on the therapeutic efficacy of many drugs. C3435T and G2677 polymorphisms of the MDR1/ABCB1 gene correlate with cellular expression levels of P-gp, a membrane-bound efflux pump which removes a multitude of drugs, including chemotherapy drugs and immunosuppressants, from cells. We aimed to investigate whether the phenomenon of drug resistance, mediated by the MDR1/ABCB1 gene and seen in tumor cells to chemotherapeutic agents, is important in the field of transplantation, predisposing some patients to resistance to immunosuppressants.
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7/31/2006
American Journal of Transplantation 2006: 6
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8/15/2008
This study aims to determine the association of CYP3A5(A6986G) and ABCB1 exon 12 (C1236T), exon26(C3435T) with early renal function in 318 kidney transplant patients.
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5/31/2008
Incidences of type 2 diabetes mellitus (DM) are significantly different among different ethnic groups in a general population. A new onset post transplant diabetes mellitus (PTDM) is an important complication after kidney transplantation and is associated with reduced overall patient and graft survival.
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5/31/2008
Elderly recipients older than age 50 have increased 3-year rates of posttransplant diabetes (17% vs 4% compared to those younger than 30). This study examines the relative impact of steroids, calcineurin inhibitors, anti-proliferatives and induction therapies on the risk of post-transplant diabetes, rejection and graft loss.
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