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12/31/2006
Gut 55: 863-868, 2006
The cytotoxic T lymphocyte antigen 4 (CTLA-4) gene encodes for a membrane bound (mCTLA-4) and a soluble (sCTLA-4) isoform, which are both involved in regulation of T cell function. The CTLA-4 +49A/G single nucleotide polymorphism (SNP) influences expression of mCTLA-4; +6230G/A SNP affects the production of sCTLA-4.
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12/31/2006
Transplantation. 82: 1298-1303, 2006
There may be an allograft-enhancing effect by the liver on the renal allograft in the setting of simultaneous combined liver-kidney transplantation (CLKT) from the same donor. This study was performed to investigate whether an existing liver allograft could protect a kidney allograft from immunologic injury due to histoincompatibility in liver transplant recipients who received sequential kidney transplantation (KALT).
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12/31/2006
Transplantation. 82: 1673-1676, 2006
New-onset diabetes mellitus after kidney transplantation (NODM) is an important co morbid condition that is associated with inferior graft and patient survival. The objective of this study was to identify donor, recipient and transplant factors, and choices of immunosuppression associated with development of NODM using Organ Procurement Transplant Network/United Network of Organ Sharing database (OPTN/UNOS).
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12/31/2006
Surgery 24: 79, 2006
The major strategies in overcoming acute and chronic rejection are to minimize immune activation to reduce the number of T-cells in the recipient to prevent activation and proliferation of T-cells, and to suppress inflammation. Etc.
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12/31/2006
Surgery 24: 47, 2006
Solid-organ transplantation has enjoyed great success over the last twenty years. Graft survival after kidney, liver or heart transplantation exceeds 90% at one year and is about 50% at 10 years in most centres in the UK. Better immunosuppressive drugs and more thorough understanding of the nature of the immune response against the graft are the reasons for this success.
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12/31/2006
Transplantation 82: 1210-1213, 2006
Human T-cell lymphotrophic virus (HTLV) type I has been linked to adult T-cell leukemia/lymphoma (ATL) and HTLV-I associated myelopathy (HAM). Transmission of HTLV by blood and organ transplantation has been documented, with some infections leading to clinical disease. Organ donors are tested for anti-HTLV antibodies and donor suitability is determined primarily by results from enzyme immunoassays (EIA). Confirmatory testing is not routinely performed, and the number of false positive organ donors is unknown.
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12/31/2006
Transplantation. 81: 477-479, 2006
Trypanosoma cruzi, a parasite that causes Chagas’ disease, is endemic in parts of Mexico, South America, and Central America. Transmission of T. cruzi infection by solid organ transplantation has been reported in Latin America and recently in the United States. To determine the prevalence of T. cruzi antibodies in Southern California organ donors, 404 samples from deceased organ donors between May 2002 to April 2004 were screened using a qualitative enzymelinkedimmunosorbent assay (EIA) and confirmed with an immunofluorescence assay (IFA) available through the Centers for Disease Control (CDC). Six donors were initially reactive by EIA. Three donors were repeatedly reactive after repeat testing and were sent to the CDC for confirmation. One donor (0.25%) had an IFA-confirmed reactivity to anti-T. cruzi antibodies. In areas where there is a high number of immigrants from T. cruzi endemic countries, screening for anti-T. cruzi donor antibodies may be beneficial.
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12/31/2006
Am J Transplant. 6: 1473-1478, 2006
The use of expanded criteria donors (ECD) has been proposed to help combat the discrepancy between organ availability and need. ECD kidneys are associated with delayed graft function (DGF) and worse long-term survival. The aim of this study is to evaluate the impact of pulsatile perfusion (PP) on DGF and graft survival in transplanted ECD kidneys. From January 2000 to December 2003, 4618 ECD kidney-alone transplants were reported to the United Network for Organ Sharing. PP was performed on 912 renal allografts. Etc.
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12/31/2006
Transplantation 82: 716-717, 2006
The utilization of donation-aftercardiac-death (DCD) donors in liver transplantation has been proposed as a way to alleviate the shortage of liver allografts. Although the use of DCD livers is increasing, there has been reluctance because of extended warm ischemic times and possible suboptimal allografts. Therefore these DCD livers tend to be transplanted in “less sick” patients.
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12/31/2006
Clin J Am Soc Nephrol. 1: 288-296, 2006
The risk for and predictors of atrial fibrillation (AF) after kidney transplantation are not well described. Registry data that were collected by the United States Renal Data System were used to investigate retrospectively new-onset AF among adult first renal allograft recipients and transplant candidates who received a transplant or were wait-listed in 1995 to 2001 with Medicare as the primary payer. AF events were ascertained from billing records, and participants were followed until loss of Medicare coverage or December 31, 2001. Etc.
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