In 1984, in affiliation with the University of Southern California's Keck School of Medicine and the Daughters of Charity Health System, the Los Angeles Transplant Institute was formed. In 1989, the Los Angeles Transplant Institute became the Mendez National Institute of Transplantation (MNIT).
The affiliation with USC and the Daughters of Charity Health System continues to this day, but MNIT remains an independent organization, unrelated to or connected with any other private organization or any government agency.