DSA ATC 2008
Despite improved early graft survival (currently over 90% at 1-year) long-term graft loss rate has not been reduced. Both HLA antibodies and HLA donor specific antibodies (DSA) have been shown to contribute to acute and chronic allograft nephropathy (CAN), particularly the former. In a longitudinal study, HLA antibodies were linked to graft failure. Recently, Class II DSA have been shown to correlate with graft failure in renal transplant recipients with grafts surviving at least one year.
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